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  • Southeast Asia

Singapore biotech start-up closes $125m Series C

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  • Tim Burroughs
  • 21 May 2021
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Novo Holdings, which manages the wealth of Denmark’s Novo Nordisk Foundation, has led a $125 million Series C round for Hummingbird Bioscience, a Singapore and US-based drug developer.

Additional contributions came from US-based Frazier Healthcare Partners, Polaris Partners, Altium Capital Management, Ally Bridge Group, Octagon Capital, and Affinity Asset Advisors, European healthcare specialists Droia Ventures and Pureos Bioventures, and the corporate VC unit of biotech multinational Amgen.

Within Asia, support came from EDBI, the corporate investment arm of the Singapore government’s Economic Development Board, and Hong Kong-headquartered Morningside Ventures.

Several existing investors re-upped, including SK Group, Heritas Capital, Seeds Capital, and Mirae Asset Venture Capital. Hummingbird’s Series B closed at $19 million in December 2019 with Mirae Asset taking the lead. A $25 million extension, led by SK, was announced in May 2020.

Proceeds from the Series C will be used to support the development of the company’s pipeline of precision therapies for hard-to-drug targets.

Hummingbird has two treatments on course to begin clinical trials this year: HMBD-001, a monoclonal antibody that focuses on HER3, a protein regarded as a potent driver of tumor growth and resistance against cancer drugs; and HMBD-002, which neutralizes a checkpoint protein that promotes resistance to immunotherapy by suppressing T-cell activity.

HMBD-001 is a product of the company’s rational antibody discovery platform. This is a computationally guided platform that identifies the critical functional regions of a target protein, drives the production of antibodies that might mitigate the protein, and isolates the ones that successfully bind to it, thereby optimizing the therapeutic potential of a treatment.

Hummingbird is also developing a treatment for lupus and a T cell engager used against multiple myeloma, a plasma cell cancer.

“We believe that Hummingbird’s novel data-driven, systems biology approach brings new precision to the field of antibody drug discovery and development, and we are proud to support the team in realizing their vision,” said Kenneth Harrison, a partner at Novo Ventures, in a statement.

Novo Nordisk Foundation holds controlling stakes in diabetes care specialist Novo Nordisk and bioinnovation player Novozymes. It has $62 billion in assets, of which $19 billion is deployed in financial and life sciences investments. The life sciences portfolio is split into four strategies based on size and maturity, with $1-2 billion in new capital deployed each year.

Novo Holdings established an Asia life sciences investment team in Singapore last year, following the recruitment of Amit Kakar as regional head. A debut Asia investment came last month with participation in an $80 million Series C round for Indonesia healthcare technology provider Halodoc.

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